Sean Mendis returned to Ghana in 2018 as Chief Operations Officer of Africa World Airlines, resuming a role he had previously held from 2010 to 2012 during the airline's startup.

From 2005 to 2010, Sean was part of the launch management team of Ghana International Airlines. In 2013, he moved to Somalia to manage Mogadishu's Aden Abdulle International Airport for SKA International Group under contract from the Somali Federal Government. Between 2014 and 2018, he helped launch multiple aviation business lines for SKA, including a jet-fuel terminal in the UAE, and a cargo airline based in Uganda.